Search Count: 14
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Pim1 In Complex With Cpd16 (5-Amino-N-(5-((4R,5R)-4-Amino-5-Fluoroazepan-1-Yl)-1-Methyl-1H-Pyrazol-4-Yl)-2-(2,6-Difluorophenyl)Thiazole-4-Carboxamide)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2019-02-27 Classification: TRANSFERASE Ligands: GOL, PO4, KUV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-27
Ligands: GOL, PO4, KUV
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Pim1 Kinase In Complex With Cpd1 (1-Methyl-4-(3-(6-(Piperazin-1-Yl)Pyridin-2-Yl)-1H-Pyrazolo[3,4-C]Pyridin-5-Yl)Piperazin-2-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2018-04-18 Classification: TRANSFERASE/INHIBITOR Ligands: PO4, 971 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-04-18
Ligands: PO4, 971
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Pim1 Kinase In Complex With Cpd17 (1-(6-(4,4-Difluoropiperidin-3-Yl)Pyridin-2-Yl)-6-(6-Methylpyrazin-2-Yl)-1H-Pyrazolo[4,3-C]Pyridine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2017-05-10 Classification: TRANSFERASE/INHIBITOR Ligands: 96Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 96Y
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Jak2 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-[(8As)-2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(8Ah)-Yl]Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor (Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexyl)Acetonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J6
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 34
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 15T |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 15T
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Structure Of Pim-1 Kinase Bound To N-(4-Fluorophenyl)-7-Hydroxy-5-(Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2013-05-15 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1OA, PO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-15
Ligands: 1OA, PO4
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Structure Of Pim-1 Kinase Bound To 5-(4-Cyanobenzyl)-N-(4-Fluorophenyl)-7-Hydroxypyrazolo[1,5-A]Pyrimidine-3-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2013-05-15 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: PO4, 1OB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-15
Ligands: PO4, 1OB
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Structure Of Pim-1 Kinase Bound To N-(5-(2-Fluorophenyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-5-((((3R,4R)-3-Fluoropiperidin-4-Yl)Methyl)Amino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2013-05-15 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: PO4, 1OC |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-15
Ligands: PO4, 1OC
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The Jak1 Kinase Domain In Complex With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.17 Å Release Date: 2012-07-04 Classification: Transferase/Transferase Inhibitor Ligands: JAK, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: JAK, EDO
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 20
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.22 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0Q2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: 0Q2
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Discovery And Optimization Of C-2 Methyl Imidazo-Pyrrolopyridines As Potent And Orally Bioavailable Jak1 Inhibitors With Selectivity Over Jak2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.82 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1RS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: 1RS
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Discovery And Optimization Of C-2 Methyl Imidazo-Pyrrolopyridines As Potent And Orally Bioavailable Jak1 Inhibitors With Selectivity Over Jak2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: JAK |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: JAK