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Co-Structure Of Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform And Brain Penetrant Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2023-07-19 Classification: TRANSFERASE Ligands: ZTV, SO4 |
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Co-Structure Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform Complexed With Brain Penetrant Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.10 Å Release Date: 2023-07-19 Classification: TRANSFERASE Ligands: ZUO |
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Cryoem Structure Of The Hcmv Pentamer Gh/Gl/Ul128/Ul130/Ul131A In Complex With Neutralizing Fabs 2C12, 7I13 And 13H11
Organism: Human betaherpesvirus 5, Homo sapiens
Method: ELECTRON MICROSCOPY Release Date: 2022-03-23 Classification: VIRAL PROTEIN/Immune System Ligands: NAG |
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Cryoem Structure Of The Hcmv Pentamer Gh/Gl/Ul128/Ul130/Ul131A In Complex With Thbd And Neutralizing Fabs Msl-109 And 13H11
Organism: Homo sapiens, Human betaherpesvirus 5
Method: ELECTRON MICROSCOPY Release Date: 2022-03-23 Classification: VIRAL PROTEIN/Immune System Ligands: NAG |
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Cryoem Structure Of The Hcmv Pentamer Gh/Gl/Ul128/Ul130/Ul131A In Complex With Nrp2 And Neutralizing Fabs 8I21 And 13H11
Organism: Human betaherpesvirus 5, Homo sapiens
Method: ELECTRON MICROSCOPY Release Date: 2022-03-23 Classification: VIRAL PROTEIN/Immune System Ligands: NAG, CA |
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The Co-Structure Of (R)-4-(6-(1-(Cyclopropylsulfonyl)Cyclopropyl)-2-(1H-Indol-4-Yl)Pyrimidin-4-Yl)-3-Methylmorpholine And A Rationally Designed Pi3K-Alpha Mutant That Mimics Atr
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2017-06-14 Classification: TRANSFERASE/SIGNALING PROTEIN/INHIBITOR Ligands: 8DV |
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The Co-Structure Of N,N-Dimethyl-4-[(6R)-6-Methyl-5-(1H-Pyrrolo[2,3- B]Pyridin-4-Yl)-4,5,6,7-Tetrahydropyrazolo[1,5- A]Pyrazin-3-Yl]Benzenesulfonamide And A Rationally Designed Pi3K-Alpha Mutant That Mimics Atr
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2017-05-10 Classification: TRANSFERASE/SIGNALING PROTEIN/INHIBITOR Ligands: 3K6 |
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The Co-Structure Of 3-Amino-6-(4-((1-(Dimethylamino)Propan-2-Yl)Sulfonyl)Phenyl)-N-Phenylpyrazine-2-Carboxamide And A Rationally Designed Pi3K-Alpha Mutant That Mimics Atr
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2017-05-10 Classification: TRANSFERASE/SIGNALING PROTEIN/INHIBITOR Ligands: 8DY |
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Organism: Acinetobacter baumannii niph 410
Method: X-RAY DIFFRACTION Resolution:1.99 Å Release Date: 2016-09-28 Classification: TRANSFERASE Ligands: SO4, NA, GOL, LMT, PO4 |
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Lipid A Secondary Acyltransferase Lpxm From Acinetobacter Baumannii With Catalytic Residue Substitution (E127A)
Organism: Acinetobacter baumannii niph 410
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2016-09-28 Classification: TRANSFERASE Ligands: SO4, GOL, LMT, 11A |
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Discovery Of Imidazo[1,2-A]-Pyridine Inhibitors Of Pan-Pi3 Kinases That Are Efficacious In A Mouse Xenograft Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2016-02-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: GOL, 5XV |
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Crystal Structure Of A Novel Tetrahydropyrazolo[1,5-A]Pyrazine In An Engineered Pi3K Alpha
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.39 Å Release Date: 2014-12-31 Classification: transferase/transferase inhibitor Ligands: 3K6 |
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Crystal Structure Of Rat Cyclophilin D In Complex With A Potent Nonimmunosuppressive Inhibitor
Organism: Rattus norvegicus, Synthetic construct
Method: X-RAY DIFFRACTION Resolution:2.39 Å Release Date: 2014-11-12 Classification: ISOMERASE/ISOMERASE Inhibitor Ligands: P6G, SO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2014-10-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: GOL, 2UG |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.50 Å Release Date: 2011-04-20 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SYP |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2011-04-20 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: MP7 |
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Crystal Structure Of Mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) In Complex With 1-(3-Chloro-Phenyl)-3-{5-[2-(Thieno[3,2-D]Pyrimidin-4-Ylamino)- Ethyl]-Thiazol-2-Yl}-Urea [Sns-314]
Organism: Mus musculus
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2009-05-12 Classification: TRANSFERASE Ligands: AK2 |
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Crystal Structure Of Mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) In Complex With 1-{5-[2-(1-Methyl-1H-Pyrazolo[4,3-D]Pyrimidin-7-Ylamino)-Ethyl]-Thiazol-2-Yl}-3-(3-Trifluoromethyl-Phenyl)-Urea
Organism: Mus musculus
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2009-05-12 Classification: TRANSFERASE Ligands: AK3 |
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Crystal Structure Of Mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) In Complex With [7-(2-{2-[3-(3-Chloro-Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3-D]Pyrimidin-1-Yl]-Acetic Acid
Organism: Mus musculus
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2009-05-12 Classification: TRANSFERASE Ligands: AK4 |
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Crystal Structure Of The Mouse Aurora-A Catalytic Domain (Asn186->Gly, Lys240->Arg, Met302->Leu) In Complex With Compound 290.
Organism: Mus musculus
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2009-05-05 Classification: TRANSFERASE Ligands: AK5 |