Search Count: 25
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Multi-Parameter Lead Optimization To Give An Oral Chk1 Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-Ylmethyl)Amino)-5-(Trifluoromethyl)Pyridin-2-Yl)Amino)Pyrazine-2-Carbonitrile (Cct245737)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.91 Å Release Date: 2016-05-25 Classification: TRANSFERASE Ligands: 5UY, EDO, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: 5UY, EDO, GOL
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Nek2-Ede Bound To Cct248662
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2012-04-25 Classification: TRANSFERASE Ligands: JUP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-04-25
Ligands: JUP
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Nek2 Bound To Hybrid Compound 21
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2012-04-25 Classification: TRANSFERASE Ligands: GGY, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-04-25
Ligands: GGY, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: YM3, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: YM3, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: 4YM, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: 4YM, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: YM5, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: YM5, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: YM6, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: YM6, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.81 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: YM7, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: YM7, EDO
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Crystal Structure Of Checkpoint Kinase 1 (Chk1) In Complex With Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.07 Å Release Date: 2012-01-11 Classification: TRANSFERASE Ligands: YM8, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: YM8, EDO
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Structure Of Nek2 Bound To Aminipyrazine Compound 5
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-11-03 Classification: TRANSFERASE Ligands: WI2, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-11-03
Ligands: WI2, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 35
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: XK3, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: XK3, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 17
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: OL2, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: OL2, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 36
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: EQH, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: EQH, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 23
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.99 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: 30E, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: 30E, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: 5R1, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: 5R1, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 14
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: 4VQ, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: 4VQ, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 12
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.96 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: T3M, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: T3M, CL
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Structure Of Nek2 Bound To Aminopyrazine Compound 2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2010-10-27 Classification: TRANSFERASE Ligands: BX1, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: BX1, CL
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Structure Of 4-(4-Tert-Butylbenzyl)-1-(7H-Pyrrolo(2,3-D)Pyrimidin-4- Yl)Piperidin-4-Amine Bound To Pkb
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.72 Å Release Date: 2010-06-16 Classification: TRANSFERASE Ligands: X37 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-06-16
Ligands: X37
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Structure Of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D)Pyrimidin- 4-Yl)Piperidine-4-Carboxamide Bound To Pkb
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2010-02-23 Classification: TRANSFERASE Ligands: X39 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-23
Ligands: X39