Search Count: 25
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 4).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.58 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YO4, YNZ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-20
Ligands: YO4, YNZ
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket (Compound 5).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.20 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YOR, YNZ, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-20
Ligands: YOR, YNZ, CL
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Pi3Ka H1047R Co-Crystal Structure With Inhibitors In Two Cryptic Pockets (Compounds 4 And 5).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.35 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YO4, YOR, YNZ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-20
Ligands: YO4, YOR, YNZ
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 12).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.93 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: 1LT, YQB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-20
Ligands: 1LT, YQB
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 7).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.61 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YQ2, 1LT |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-20
Ligands: YQ2, 1LT
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Crystal Structure Of Sos1 With Mrtx0902, A Potent And Selective Inhibitor Of The Sos1:Kras Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NKF |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NKF
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Crystal Structure Of Sos1 With Phthalazine Inhibitor Bound (Compound 15)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.29 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NL0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NL0
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Prmt5/Mep50 Crystal Structure With Sinefungin Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.21 Å Release Date: 2022-03-16 Classification: TRANSFERASE/INHIBITOR Ligands: SFG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-03-16
Ligands: SFG
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Prmt5/Mep50 Crystal Structure With Mta And Phthalazinone Fragment Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2022-01-26 Classification: TRANSFERASE Ligands: CL, NA, EDO, 81X, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: CL, NA, EDO, 81X, MTA
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Prmt5/Mep50 Crystal Structure With Mta And A Phthalazinone Inhibitor Bound (Compound 9)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.78 Å Release Date: 2022-01-26 Classification: TRANSFERASE/INHIBITOR Ligands: MTA, 84W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: MTA, 84W
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Prmt5/Mep50 Crystal Structure With Mta And A Phthalazinone Inhibitor Bound (Compound (M)-31)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2022-01-26 Classification: TRANSFERASE/INHIBITOR Ligands: MTA, 85E |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: MTA, 85E
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Prmt5/Mep50 Crystal Structure With Mta And Mrtx-1719 Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.62 Å Release Date: 2022-01-26 Classification: TRANSFERASE/INHIBITOR Ligands: MTA, 85K |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: MTA, 85K
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Prmt5/Mep50 With Compound 30 Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.14 Å Release Date: 2022-01-26 Classification: TRANSFERASE/INHIBITOR Ligands: 97L, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: 97L, MTA
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Prmt5/Mep50 With Compound 29 Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2022-01-26 Classification: TRANSFERASE/INHIBITOR Ligands: 97X, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-26
Ligands: 97X, MTA
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
 |
Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG