Search Count: 11
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Crystal Structure Of Human Hras G12C Covalently Bound To Amg 510
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2024-07-31 Classification: ONCOPROTEIN Ligands: GDP, MOV, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-07-31
Ligands: GDP, MOV, MG
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Crystal Structure Of Sos1 With Mrtx0902, A Potent And Selective Inhibitor Of The Sos1:Kras Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NKF |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NKF
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Crystal Structure Of Sos1 With Phthalazine Inhibitor Bound (Compound 15)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.29 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NL0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NL0
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Kras G12D (Gppcp) With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: 6IC, GCP, GDP, GOL, ACT, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-03-16
Ligands: 6IC, GCP, GDP, GOL, ACT, MG
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
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Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG
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Type 6 Secretion Amidase Effector 2 (Tae2)
Organism: Salmonella typhi
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2020-04-22 Classification: ANTIMICROBIAL PROTEIN |
Organism: Salmonella typhi
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22