Search Count: 75
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Multi-Parameter Lead Optimization To Give An Oral Chk1 Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-Ylmethyl)Amino)-5-(Trifluoromethyl)Pyridin-2-Yl)Amino)Pyrazine-2-Carbonitrile (Cct245737)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.91 Å Release Date: 2016-05-25 Classification: TRANSFERASE Ligands: 5UY, EDO, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: 5UY, EDO, GOL
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Pka-S6K1 Chimera Apo
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
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Pka-S6K1 Chimera With Staurosporine Bound
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR Ligands: STU, GOL, MG8 |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
Ligands: STU, GOL, MG8
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Pka-S6K1 Chimera With Compound 1 (Nu1085) Bound
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:2.19 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR Ligands: NU3, MPD |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
Ligands: NU3, MPD
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Pka-S6K1 Chimera With Compound 15E (Cct147581) Bound
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR Ligands: ZO9, MOH |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
Ligands: ZO9, MOH
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Pka-S6K1 Chimera With Compound 21A (Cct196539) Bound
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR Ligands: Z21, MPD |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
Ligands: Z21, MPD
 |
Pka-S6K1 Chimera With Compound 21E (Cct239066) Bound
Organism: Bos taurus
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2013-10-09 Classification: TRANSFERASE/INHIBITOR Ligands: VUP, MOH |
Organism: Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2013-10-09
Ligands: VUP, MOH
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: NO3, EDO, VFB, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: NO3, EDO, VFB, CL
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: NO3, EDO, ODO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: NO3, EDO, ODO
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: ODH, NO3, CL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: ODH, NO3, CL, EDO
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.67 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: EDO, Z0O, NO3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: EDO, Z0O, NO3
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.55 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: NO3, EDO, CWS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: NO3, EDO, CWS
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: H3R, NO3, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: H3R, NO3, EDO
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.84 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: P3J, NO3, EDO, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: P3J, NO3, EDO, CL
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: NO3, WVI, EDO, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: NO3, WVI, EDO, CL
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.32 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: HAU, NO3, CL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: HAU, NO3, CL, EDO
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.01 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: Z2M, NO3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: Z2M, NO3
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Fragment-Based Screening Identifies A New Area For Inhibitor Binding To Checkpoint Kinase 2 (Chk2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.30 Å Release Date: 2013-06-26 Classification: TRANSFERASE Ligands: RQQ, NO3, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-26
Ligands: RQQ, NO3, EDO
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Nek2-Ede Bound To Cct248662
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2012-04-25 Classification: TRANSFERASE Ligands: JUP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-04-25
Ligands: JUP
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Nek2 Bound To Hybrid Compound 21
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2012-04-25 Classification: TRANSFERASE Ligands: GGY, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-04-25
Ligands: GGY, EDO