ISDA: 9ZXN

Deposition Date 2026-01-05

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9ZXN

Keywords:

LIGASE

Title:

DDB1 delta with compound 26

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.07 Å

R-Value Free:

0.23

R-Value Work:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:856
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q16531 Pfam ID:PF10433, PF03178

Ligand Molecules

A1C4F

GOL

Primary Citation

DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site

Reddy Guduru, S.K, Caldwell, J.P, Digianantonio, K.M, Prophet, S.M, Yang, S, Gareiss, P, Jones, C, Harbin, A, Driscoll, B, Karim, M.F, Scott, A, Patel, A, Chapman, A.E, Crandall, M, Miklossy, G, Barczak, N.T, Stroppa, A.P, Corradi, J.P, Clark, J.J, Chung, M.K, Reinhardt, N.R, Butcher, W.E, Wilson, R, Stiff, C, Fathizadeh, A, Yuan, L, Wang, G, Dong, H, Beno, B.R, Zimmermann, K, Langley, D.R, Cacace, A.M, Bekes, M.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.6c00003

Primary Citation of related structures

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