ISDA: 9ZFO

Deposition Date 2025-12-01

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9ZFO

Keywords:

SIGNALING PROTEIN

Title:

Cryo-EM Structure of Human STAT2-USP18-ISG15 Complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.05 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like protein ISG15
Chain IDs:C (auth: I)
Chain Length:157
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Signal transducer and activat
Chain IDs:B (auth: S)
Chain Length:713
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Ubl carboxyl-terminal hydrola
Chain IDs:A (auth: U)
Chain Length:347
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

Huynh, K.W, Plumb, R, Healy, D.R, Jove, V, Ralph, E.C, Lee, C.W, Wheeler, H, Levine, K, Huang, Z, Fennell, K, Corpina, R.A, Craig, T, Wes, P.D, Loria, P.M, Schenone, M, Han, S, Wang, F, Wu, H, Yamaguchi, M.Show

Biorxiv ? ? ? (2026)

DOI: 10.64898/2026.02.12.705587

Primary Citation of related structures

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