ISDA: 9Z5T

Deposition Date 2025-11-12

Release Date 2026-02-04

Last Version Date 2026-02-04

Entry Detail

PDB ID:

9Z5T

Keywords:

LIGASE

Title:

Crystal structure of the transpeptidase domain of PBP2 from the Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with boronate inhibitor VNRX-14079

Biological Source:

Source Organism(s):

Neisseria gonorrhoeae (Taxon ID: 485)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable peptidoglycan D,D-tr
Gene (Uniprot):penA
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Neisseria gonorrhoeae

UniProt ID:F2Z7K9

Ligand Molecules

A1C02

Primary Citation

A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae

Uehara, T, Zulli, A.L, Miller, B, Avery, L.M, Boyd, S.A, Chatwin, C.L, Chu, G.H, Drager, A, Edwards, M, Hart, S.E, Myers, C.L, Rongola, G, Stevenson, A, Uehara, K, Yi, F, Wang, B, Liu, Z, Wang, M, Zhao, Z, Zhao, X, Zhao, H, Stratton, C.M, Bala, S, Davies, C, Travc, R, Jerse, A.E, Pevear, D.C, Burns, C.J, Daigle, D.M, Condon, S.M.Show

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Primary Citation of related structures

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