ISDA: 9Z2S

Deposition Date 2025-11-05

Release Date 2026-03-18

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9Z2S

Keywords:

TRANSFERASE

Title:

Structure of KIT V654A mutant with Compound 11

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.22

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Mast/stem cell growth factor
Mutagens:V654A
Chain IDs:A
Chain Length:359
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1CZ3

DMS

EDO

Primary Citation

Design and Synthesis of BLU-654, a Potent and Selective Mutant KIT V654A Inhibitor for the Treatment of Imatinib-Resistant GIST.

Moine, L, Hu, W, Davis, A, Perola, E, Guo, J, Barvian, K, Choi, Y.S, Grassian, A, Kim, J.L, Ahmad, O.K, Dineen, T.A.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41807293 DOI: 10.1021/acs.jmedchem.5c03554

Primary Citation of related structures

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