9Z2H image
Deposition Date 2025-11-05
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9Z2H
Keywords:
IMMUNE SYSTEM
Title:
Crystal structure of A10 Fab in complex with the EGFR peptide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Mus musculus
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.45 Å
R-Value Free:
0.22
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 32 2 1
9Z2H validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A, D (auth: E)
Chain Length:24
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P00533 EC:2.7.10.1
Polymer Type:polypeptide(L)
Molecule:Fab heavy chain of the A10 an
Chain IDs:B (auth: H), E (auth: HH)
Chain Length:247
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Fab light chain of the A10 an
Chain IDs:C (auth: L), F (auth: LL)
Chain Length:214
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
ACT
Primary Citation
Targeting cancer expressed EGFR with a humanized monoclonal antibody.
Sci Rep 16 ? ? (2026)
PMID: 41904250 DOI: 10.1038/s41598-026-46245-y
Primary Citation of related structures
9Z2H
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