9YRG image
Deposition Date 2025-10-16
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9YRG
Keywords:
CONTRACTILE PROTEIN
Title:
Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH undocked state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Saccharomyces cerevisiae (Taxon ID: 4932)
Aequorea victoria (Taxon ID: 6100)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Mus musculus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YRG validation report
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin-7,General control tran
Gene (Uniprot):GCN4, MYH7, GFP
Chain IDs:A, B
Chain Length:1315
Number of Molecules:2
Biological Source:Homo sapiens, Saccharomyces cerevisiae, Aequorea victoria
UniProt ID:P12883,P03069,P42212 Pfam ID:PF02736, PF00063, PF07716
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin light chain 1/3, skele
Gene (Uniprot):Myl1
Chain IDs:C, D
Chain Length:188
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:P05977
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin regulatory light chain
Gene (Uniprot):Myl11
Chain IDs:E, F
Chain Length:169
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:P97457 Pfam ID:PF13405
Ligand Molecules
ADP
PO4
Primary Citation
Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart
To Be Published ? ? ? (?)
Primary Citation of related structures
9YRG
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