ISDA: 9YMT

Deposition Date 2025-10-10

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9YMT

Keywords:

TRANSFERASE/INHIBITOR

Title:

Staphylococcus aureus serine/threonine kinase Stk1 with inhibitor GW779439X

Biological Source:

Source Organism(s):

Staphylococcus aureus subsp. aureus N315 (Taxon ID: 158879)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.07 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Serine/Threonine Kinase
Chain IDs:A
Chain Length:293
Number of Molecules:1
Biological Source:Staphylococcus aureus subsp. aureus N315

Ligand Molecules

A1CYJ

BEN

DMS

Primary Citation

Stk1 is required for BlaR1-mediated broad-spectrum beta-lactam resistance in epidemic-causing strains of Staphylococcus aureus.

Chatterjee, S, Poon, R, Satishkumar, N, Mosimann, W, Hayatnagarkar, V, Hemmadi, V, Kuhn, S, Chatterjee, A, Worrall, L, Manes, N, Alexander, J.A, Lack, J, Chambers, H, Nita-Lazar, A, Strynadka, N.Show

Res Sq ? ? ? (2026)

PMID: 41743328 DOI: 10.21203/rs.3.rs-8331258/v1

Primary Citation of related structures

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