ISDA: 9YK0

Deposition Date 2025-10-06

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9YK0

Keywords:

PLANT PROTEIN

Title:

cryoEM structure of Aspergillus fumigatus acetolactate synthase (ALS) in complex with a novel inhibitor

Biological Source:

Source Organism(s):

Aspergillus fumigatus (Taxon ID: 746128)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.36 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Acetolactate synthase
Chain IDs:A, B
Chain Length:641
Number of Molecules:2
Biological Source:Aspergillus fumigatus

Ligand Molecules

A1CXH

FAD

TPP

Primary Citation

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.

Perlatti, B, Vellanki, S, Zhang, Y, Chiang, Y.M, Hu, Y, Yuan, M, Dunbar, K, Fine, A, Grau, M.F, Li, S, O'Donnell, T, Shenoy, R, Li, H, Shi, H, Xu, X, Chen, Z, Arvedson, T, Tang, Y, Cramer, R.A, Cee, V, Harvey, C.J.B.Show

Acs Cent.Sci. 12 197 207 (2026)

PMID: 41768770 DOI: 10.1021/acscentsci.5c02019

Primary Citation of related structures

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