ISDA: 9Y8N

Deposition Date 2025-09-11

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9Y8N

Keywords:

LIGASE

Title:

Crystal structure of the Kelch domain of human KLHL12 with compound 8m

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.31 Å

R-Value Free:

0.20

R-Value Work:

0.15

Space Group:

P 41 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Kelch-like protein 12
Gene (Uniprot):KLHL12
Chain IDs:A
Chain Length:295
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q53G59 Pfam ID:PF01344, PF24681

Ligand Molecules

A1CTL

Primary Citation

Identification of KLHL12 Ligands Using Fragment-Based Methods.

Waterson, A.G, Vadukoot, A, Jana, S, Cui, J, Luong, K, Rietz, T.A, Madrigal-Carrillo, E.A, Lehmann, B.D, Sensintaffar, J.L, Zhao, B, Amporndanai, K, Petros, Z.A, Scaggs, W.R, Chacon Simon, S, Vekariya, R.H, Kim, K, Thangaraj, M, Christov, P.P, South, T.M, Sai, J, Thiruvaipati, A, Schmidt, C.R, Eells, R, Moore, W.J, Olejniczak, E.T, Phan, J, Fesik, S.W.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41906311 DOI: 10.1021/acs.jmedchem.5c02931

Primary Citation of related structures

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