ISDA: 9XY4

Deposition Date 2025-08-25

Release Date 2026-04-01

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9XY4

Keywords:

SIGNALING PROTEIN

Title:

Zymogen ADAM17- iRhom1 Cytoplasmic Deletion (370) Complex Bound by the MEDI3622 Fab

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.12 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Inactive rhomboid protein 1
Chain IDs:A
Chain Length:429
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Disintegrin and metalloprotei
Chain IDs:D (auth: B)
Chain Length:671
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MEDI3622 Fab Heavy Chain
Chain IDs:B (auth: C)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MEDI3622 Fab Light Chain
Chain IDs:C (auth: D)
Chain Length:216
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules