9X22 image
Deposition Date 2025-10-03
Release Date 2026-03-25
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9X22
Keywords:
SIGNALING PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM structure of the GLP-1-bound human GLP-1R-Gq complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni, Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.92 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9X22 validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:G subunit q (Gi2-mini-Gq chim
Chain IDs:C (auth: A)
Chain Length:246
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:D (auth: B)
Chain Length:358
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:E (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1(7-36)
Gene (Uniprot):GCG
Chain IDs:A (auth: P)
Chain Length:30
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01275 Pfam ID:PF00123
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:B (auth: R)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43220 Pfam ID:PF02793, PF00002
Ligand Molecules
NA
Primary Citation
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors
Acta Pharm Sin B ? ? ? (2026)
DOI: 10.1016/j.apsb.2026.01.023
Primary Citation of related structures
9X22
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