ISDA: 9X1W

Deposition Date 2025-10-03

Release Date 2026-02-18

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9X1W

Keywords:

DE NOVO PROTEIN

Title:

Crystal structure of de novo designed complement C9 mini-inhibitor form 1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.46 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:P57-M4
Chain IDs:A
Chain Length:92
Number of Molecules:1
Biological Source:Homo sapiens

Primary Citation

Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly.

Nat Commun ? ? ? (2026)

PMID: 41813685 DOI: 10.1038/s41467-026-70667-x

Primary Citation of related structures