ISDA: 9WRN

Deposition Date 2025-09-12

Release Date 2026-02-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9WRN

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of chimeric anti-Z-DNA Fab cZ22-Fab

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.15 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:cZ22-Fab heavy chain
Chain IDs:A (auth: H), B (auth: I), C (auth: J), D (auth: K)
Chain Length:236
Number of Molecules:4
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:cZ22-Fab light chain
Chain IDs:E (auth: L), F (auth: M), G (auth: N), H (auth: O)
Chain Length:214
Number of Molecules:4
Biological Source:Mus musculus

Primary Citation

Structural basis of B-to-Z DNA transition mediated by an anti-Z-DNA antibody.

Lee, C.C, Hsu, S.F, Chang, Y.W, Chen, Y.W, Ho, M.R, Sugiyama, H, Wang, W.C, Wang, A.H.Show

Nucleic Acids Res. 54 ? ? (2026)

PMID: 41761907 DOI: 10.1093/nar/gkag160

Primary Citation of related structures

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