ISDA: 9WQS

Deposition Date 2025-09-11

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9WQS

Keywords:

LIGASE

Title:

Crystal structure of Saccharomyces cerevisiae isoleucyl-tRNA synthetase in complex with reveromycin A and isoleucine

Biological Source:

Source Organism(s):

Saccharomyces cerevisiae S288C (Taxon ID: 559292)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoleucine--tRNA ligase, cyto
Gene (Uniprot):ILS1
Chain IDs:A
Chain Length:990
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P09436 Pfam ID:PF00133, PF08264, PF19302 EC:6.1.1.5

Ligand Molecules

EDO

GVU

ILE

Primary Citation

Substrate l-isoleucine facilitates the hyper inhibition of reveromycin A on human cytoplasmic isoleucyl-tRNA synthetase.

Chen, B, Yi, F, Qi, H, Xu, J, Su, J, Zhou, H, Liu, H.Show

Arch.Biochem.Biophys. 780 110789 110789 (2026)

PMID: 41839287 DOI: 10.1016/j.abb.2026.110789

Primary Citation of related structures

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