ISDA: 9WIQ

Deposition Date 2025-08-29

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9WIQ

Keywords:

HYDROLASE

Title:

Crystal structure of ADC-227 in the avibactam complex (50 mM for 4 hour)

Biological Source:

Source Organism(s):

Acinetobacter baumannii (Taxon ID: 470)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 31 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Beta-lactamase
Chain IDs:A
Chain Length:363
Number of Molecules:1
Biological Source:Acinetobacter baumannii

Ligand Molecules

NXL

Primary Citation

Stable cefiderocol resistance mediated by a valine substitution at position 293 combined with an alanine duplication in the omega loop of ADC beta-lactamase in Acinetobacter baumannii

Kawai, A, Doi, Y.Show

Mbio ? ? ? (2026)

DOI: 10.1128/mbio.03518-25

Primary Citation of related structures

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