9WDP image
Deposition Date 2025-08-19
Release Date 2026-01-14
Last Version Date 2026-01-14
Entry Detail
PDB ID:
9WDP
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
Cyro-EM structure of prefusion RSV fusion glycoprotein in complex with Ziresovir and motavizumab Fab
Biological Source:
Source Organism(s):
Human respiratory syncytial virus A2 (Taxon ID: 11259)
Tequatrovirus T4 (Taxon ID: 10665)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.27 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9WDP validation report
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fusion glycoprotein F0,Fibrit
Gene (Uniprot):F, wac
Chain IDs:A, B, C
Chain Length:593
Number of Molecules:3
Biological Source:Human respiratory syncytial virus A2, Tequatrovirus T4
UniProt ID:P03420,P10104
Polymer Type:polypeptide(L)
Molecule:Motavizumab Fab heavy chain
Chain IDs:D, F, H
Chain Length:225
Number of Molecules:3
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:Motavizumab Fab light chain
Chain IDs:E, G, I (auth: L)
Chain Length:213
Number of Molecules:3
Biological Source:Mus musculus
Ligand Molecules
A1EV1
Primary Citation
Molecular Mechanism of Ziresovir Targeting the Fusion Glycoprotein of Respiratory Syncytial Virus
To Be Published ? ? ? (?)
Primary Citation of related structures
9WDP
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