9VUV image
Deposition Date 2025-07-14
Release Date 2026-02-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9VUV
Keywords:
VIRAL PROTEIN
Title:
Crystal structure of SADS-CoV main protease (Lys35Val/Cys224Ser) in complex with SY110
Biological Source:
Source Organism(s):
Swine acute diarrhea syndrome coronavirus (Taxon ID: 2032731)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 21 21 2
9VUV validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ORF1ab polyprotein
Gene (Uniprot):orf1ab
Mutagens:K35V,C224S
Chain IDs:A (auth: B), B (auth: A)
Chain Length:301
Number of Molecules:2
Biological Source:Swine acute diarrhea syndrome coronavirus
UniProt ID:A0A2P1G738 Pfam ID:PF05409
Ligand Molecules
LVX
P33
PG4
Primary Citation
An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases.
Plos Pathog. 22 e1013981 e1013981 (2026)
PMID: 41734227 DOI: 10.1371/journal.ppat.1013981
Primary Citation of related structures
9VUV
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