ISDA: 9VNH

Deposition Date 2025-06-30

Release Date 2026-04-01

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9VNH

Keywords:

CELL INVASION

Title:

Structure of wild-type RhoA in complex with GDP and magnesium ion

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.23

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transforming protein RhoA
Gene (Uniprot):RHOA
Chain IDs:A
Chain Length:182
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61586 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

GDP

Primary Citation

Discovering Targetable Conformation of RhoA Mutant by Integrating Native Mass Spectrometry, Ultraviolet Photodissociation, and X-ray Diffraction.

Wu, H, Liu, Z, Jiang, H, Zhao, H, Dong, C, Lu, Y, Zu, S, Guo, Y, Lai, C, Luo, P, Xu, K, Yang, Y, Yang, Y, Sun, Z, Huang, Q, Xiong, H, Zhou, L, Luo, Y, Zeng, Y, Du, D, Liang, Z, Xiao, W, Zhao, S, Zhang, W, Tang, Y, Xiao, C, Chen, K, Yang, X, Wang, F, Luo, C.Show

J.Am.Chem.Soc. 148 11709 11718 (2026)

PMID: 41837560 DOI: 10.1021/jacs.5c20067

Primary Citation of related structures

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