ISDA: 9V2Q

Deposition Date 2025-05-20

Release Date 2025-12-31

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9V2Q

Keywords:

VIRAL PROTEIN

Title:

Cryo-EM structure of RSV pre-F dimer in complex with CNR2056/CNR2047

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Respiratory syncytial virus A2 (Taxon ID: 1972429)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.43 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:CNR2056 heavy chain
Chain IDs:A, F
Chain Length:126
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RSV Pre-fusion Protein
Chain IDs:B, G
Chain Length:553
Number of Molecules:2
Biological Source:Respiratory syncytial virus A2

UniProt ID:P03420

Polymer Type:polypeptide(L)
Molecule:CNR2056 light chain
Chain IDs:C, H
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:CNR2047 heavy chain
Chain IDs:D, I
Chain Length:121
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:CNR2047 light chain
Chain IDs:E, J
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV.

Zhai, H, Yu, W, Wang, J, Deng, J, Lei, S, Zhou, T, Li, Y, Xu, K, Ma, M, Feng, R, Hu, Y, Ren, L, Cao, Y, Liu, E, Wang, X.Show

Sci Transl Med 18 eadz4170 eadz4170 (2026)

PMID: 41706868 DOI: 10.1126/scitranslmed.adz4170

Primary Citation of related structures

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