9V0T image
Deposition Date 2025-05-18
Release Date 2025-12-31
Last Version Date 2026-03-04
Entry Detail
PDB ID:
9V0T
Keywords:
VIRAL PROTEIN
Title:
Cryo-EM structure of hMPV pre-F in complex with antibody CNR2047
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Human metapneumovirus A (Taxon ID: 3037664)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.12 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9V0T validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:CNR2047 heavy chain
Chain IDs:A (auth: D)
Chain Length:121
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:CNR2047 light chain
Chain IDs:B (auth: E)
Chain Length:110
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:hMPV fusion protein
Chain IDs:C (auth: F)
Chain Length:542
Number of Molecules:1
Biological Source:Human metapneumovirus A
UniProt ID:Q8B9P0
Ligand Molecules
NA
Primary Citation
Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV.
Sci Transl Med 18 eadz4170 eadz4170 (2026)
PMID: 41706868 DOI: 10.1126/scitranslmed.adz4170
Primary Citation of related structures
9V0T
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