ISDA: 9UA8

Deposition Date 2025-03-31

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9UA8

Keywords:

HYDROLASE

Title:

structure of PTP-MEG2 and IFG1R-pY1165/pY1166 peptide complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein phosphatase
Chain IDs:A, C (auth: B), E (auth: D), G
Chain Length:305
Number of Molecules:4
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:THR-ASP-PTR-PTR-ARG
Chain IDs:B (auth: F), D (auth: C), F (auth: E), H
Chain Length:6
Number of Molecules:4
Biological Source:Homo sapiens

Primary Citation

PTPN9 dephosphorylates IGF1R Y1165/1166 and alleviates IGF1R-mediated resistance to tyrosine kinase inhibitor in cholangiocarcinoma.

Hu, J.M, Liu, H.Q, Zhang, M.H, Chen, T.L, Shi, A.D, Gao, Q, Liu, Y.J, Wang, X, Sun, K.Y, Deng, J, Xu, Y.F, Pan, C, Li, K.S, Zhang, Z.L.Show

J Exp Clin Cancer Res 44 332 332 (2025)

PMID: 41275311 DOI: 10.1186/s13046-025-03594-2

Primary Citation of related structures

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