ISDA: 9UA5

Deposition Date 2025-03-31

Release Date 2026-01-07

Last Version Date 2026-01-07

Entry Detail

PDB ID:

9UA5

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

RABV G binding with CTB011 Fab and CTB012 Fab

Biological Source:

Source Organism(s):

Lyssavirus rabies (Taxon ID: 11292)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.94 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glycoprotein
Gene (Uniprot):G
Chain IDs:A (auth: C)
Chain Length:399
Number of Molecules:1
Biological Source:Lyssavirus rabies

UniProt ID:R9W5Z3 Pfam ID:PF00974

Polymer Type:polypeptide(L)
Molecule:CTB012 Fab light chain
Chain IDs:D
Chain Length:111
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:CTB011 Fab Heavy chain
Chain IDs:B (auth: G)
Chain Length:119
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:CTB012 Fab heavy chain
Chain IDs:E (auth: H)
Chain Length:118
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:CTB011 Fab light chain
Chain IDs:C (auth: K)
Chain Length:106
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

Primary Citation

Structural basis for broad neutralization of rabies virus by an antibody cocktail SYN023.

Cao, L, Qu, J, Zhang, C, Chen, R, Wang, J, Fehlner-Gardiner, C, Niezgoda, M, Satheshkumar, P.S, Wang, X, Tsao, E.Show

Emerg Microbes Infect 14 2547724 2547724 (2025)

PMID: 40827441 DOI: 10.1080/22221751.2025.2547724

Primary Citation of related structures

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