9U7R image
Deposition Date 2025-03-25
Release Date 2026-04-01
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9U7R
Keywords:
HYDROLASE
Title:
Substrate-free human 26S proteasome purified by midnolin, 20S proteasome, RPTs and RPN11 part
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.17 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9U7R validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC2
Chain IDs:B (auth: A)
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC1
Chain IDs:C (auth: B)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC5
Chain IDs:D (auth: C)
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC4
Chain IDs:E (auth: D)
Chain Length:418
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome 26S subunit, ATPas
Gene (Uniprot):PSMC6
Chain IDs:F (auth: E)
Chain Length:403
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A0A087X2I1 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC3
Chain IDs:G (auth: F)
Chain Length:439
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:H (auth: G), V (auth: g)
Chain Length:245
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P60900 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:I (auth: H), W (auth: h)
Chain Length:233
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25787 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:J (auth: I), X (auth: i)
Chain Length:260
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:K (auth: J), Y (auth: j)
Chain Length:247
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O14818 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:L (auth: K), Z (auth: k)
Chain Length:240
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28066 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform Long of Proteasome su
Gene (Uniprot):PSMA1
Chain IDs:M (auth: L), AA (auth: l)
Chain Length:268
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25786 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:N (auth: M), BA (auth: m)
Chain Length:254
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25788 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:O (auth: N), CA (auth: n)
Chain Length:238
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28072 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:P (auth: O), DA (auth: o)
Chain Length:276
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q99436 Pfam ID:PF00227, PF12465
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:Q (auth: P), EA (auth: p)
Chain Length:204
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49720 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:R (auth: Q), FA (auth: q)
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49721 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:S (auth: R), GA (auth: r)
Chain Length:262
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28074 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:T (auth: S), HA (auth: s)
Chain Length:240
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P20618 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:U (auth: T), IA (auth: t)
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28070 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:A (auth: c)
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00487 Pfam ID:PF01398, PF23594
Ligand Molecules
ADP
ATP
LDZ
MG
ZN
Peptide-like Molecules
PRD_000907
Primary Citation
Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover.
Nat Commun 17 ? ? (2026)
PMID: 41896529 DOI: 10.1038/s41467-026-71002-0
Primary Citation of related structures
9U7R
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