ISDA: 9U5Y

Deposition Date 2025-03-22

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9U5Y

Keywords:

BIOSYNTHETIC PROTEIN

Title:

Crystal structure of cytochrome P450 mutant-T288G S289Q G290E T291I of CYP161H12 from Amycolatopsis pretoriensis

Biological Source:

Source Organism(s):

Amycolatopsis pretoriensis (Taxon ID: 218821)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 43 21 2

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Pentalenolactone synthase
Mutagens:T288G S289Q G290E T291I
Chain IDs:A
Chain Length:396
Number of Molecules:1
Biological Source:Amycolatopsis pretoriensis

Ligand Molecules

HEM

Primary Citation

Reshape the Active Pocket of ApPT for Divergent Synthesis of Pentacyclic Triterpenoids with Expanded Chemical Space in B-Ring.

Zhang, X.W, Wang, Y.X, Dong, L.B.Show

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Primary Citation of related structures

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