9U4M image
Deposition Date 2025-03-19
Release Date 2026-03-25
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9U4M
Keywords:
HYDROLASE
Title:
Focused refinement of 19S in the substrate-engaged human 26S proteasome bound to midnolin with RPT6 at top of spiral staircase
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.14 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9U4M validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC2
Chain IDs:J (auth: A)
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC1
Chain IDs:D (auth: B)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC5
Chain IDs:K (auth: C)
Chain Length:309
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC4
Chain IDs:L (auth: D)
Chain Length:349
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome 26S subunit, ATPas
Gene (Uniprot):PSMC6
Chain IDs:M (auth: E)
Chain Length:403
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A0A087X2I1 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC3
Chain IDs:N (auth: F)
Chain Length:439
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD1
Chain IDs:H (auth: U)
Chain Length:953
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99460 Pfam ID:PF21505, PF01851, PF13646, PF18004 EC:5.6.1.5
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD3
Chain IDs:P (auth: V)
Chain Length:533
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43242 Pfam ID:PF25573, PF01399, PF08375
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD12
Chain IDs:I (auth: W)
Chain Length:456
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00232 Pfam ID:PF22241, PF01399, PF18098
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD11
Chain IDs:O (auth: X)
Chain Length:422
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00231 Pfam ID:PF18055, PF01399, PF18503
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD6
Chain IDs:A (auth: Y)
Chain Length:389
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15008 Pfam ID:PF10602, PF01399, PF21154
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD7
Chain IDs:F (auth: Z)
Chain Length:324
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P51665 Pfam ID:PF01398, PF13012
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD13
Chain IDs:B (auth: a)
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UNM6 Pfam ID:PF22037, PF01399
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD4
Chain IDs:R (auth: b)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P55036 Pfam ID:PF13519, PF02809
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:E (auth: c)
Chain Length:309
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00487 Pfam ID:PF01398, PF23594
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD8
Chain IDs:Q (auth: d)
Chain Length:349
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P48556 Pfam ID:PF10075
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome complex subuni
Gene (Uniprot):SEM1
Chain IDs:G (auth: e)
Chain Length:403
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60896 Pfam ID:PF05160
Polymer Type:polypeptide(L)
Molecule:substrate peptide
Chain IDs:C (auth: v)
Chain Length:533
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
ADP
ATP
MG
ZN
Primary Citation
Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover.
Nat Commun 17 ? ? (2026)
PMID: 41896529 DOI: 10.1038/s41467-026-71002-0
Primary Citation of related structures
9U4M
Feedback Form
Name
Email
Institute
Feedback