ISDA: 9TNR

Deposition Date 2025-12-16

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9TNR

Keywords:

DNA

Title:

L12 G-quadruplex-forming aptamer targeting HMGB1 protein

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

100

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

Download Validation Report

Macromolecular Entities

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (26-MER)
Chain IDs:A
Chain Length:26
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Unraveling the NMR structures of G-quadruplex-forming aptamers acting as inhibitors of High Mobility Group Box 1 (HMGB1) pathological activity.

Trajkovski, M, Platella, C, Musumeci, D, Napolitano, E, Esposito, C.L, Catuogno, S, Plavec, J, Montesarchio, D.Show

Int.J.Biol.Macromol. 357 151585 151585 (2026)

PMID: 41881226 DOI: 10.1016/j.ijbiomac.2026.151585

Primary Citation of related structures

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