ISDA: 9TM2

Deposition Date 2025-12-11

Release Date 2026-04-01

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9TM2

Keywords:

OXIDOREDUCTASE

Title:

Plasmodium falciparum dihydroorotate dehydrogenase in complex with 3-hydroxy-1-methyl pyrazole derivatives

Biological Source:

Source Organism(s):

Plasmodium falciparum (Taxon ID: 5833)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.26

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydroorotate dehydrogenase
Gene (Uniprot):PFF0160c
Chain IDs:A, B
Chain Length:405
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:Q08210 Pfam ID:PF01180

Ligand Molecules

A1JWQ

FMN

ORO

Primary Citation

Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).

Pippione, A.C, Villella, N, Fornaseri, F, Giorgis, M, Sharma, M, Rolando, B, Sainas, S, Salamanca, E, Gimenez, A, Cojean, S, Vyas, V.K, Buccinna, B, Ramondetti, C, Piccinini, M, Poli, G, Tuccinardi, T, Alberti, M, Miggiano, R, Lolli, M.L, Boschi, D.Show

Eur.J.Med.Chem. 309 118753 118753 (2026)

PMID: 41855879 DOI: 10.1016/j.ejmech.2026.118753

Primary Citation of related structures

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