9T9W image
Deposition Date 2025-11-17
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9T9W
Keywords:
TRANSFERASE
Title:
Crystal structure of beta-TrCP bound by diphosphorylated I-kappa-B-alpha degron peptide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.16 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 21 21 21
9T9W validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:F-box/WD repeat-containing pr
Gene (Uniprot):BTRC
Chain IDs:A
Chain Length:365
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y297 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:NF-kappa-B inhibitor alpha
Gene (Uniprot):NFKBIA
Chain IDs:B (auth: C)
Chain Length:12
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P25963
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP B SER modified residue
Ligand Molecules
EDO
Primary Citation
Structural Studies of beta TrCP Reveal Plasticity in Binding Modes of Consensus and Nonconsensus Degrons.
Acs Chem.Biol. ? ? ? (2026)
PMID: 41891920 DOI: 10.1021/acschembio.5c01007
Primary Citation of related structures
9T9W
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