ISDA: 9T4V

Deposition Date 2025-11-02

Release Date 2025-11-19

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9T4V

Keywords:

DNA BINDING PROTEIN

Title:

ALC1/CHD1L in an intermediate conformation, bound to a PARylated nucleosome

Biological Source:

Source Organism(s):

Xenopus laevis (Taxon ID: 8355)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

6.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H3.2
Chain IDs:A, E
Chain Length:136
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P84233 Pfam ID:PF00125

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H4
Chain IDs:B, F
Chain Length:103
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P62799 Pfam ID:PF15511

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2A type 1
Chain IDs:C, G
Chain Length:130
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P06897 Pfam ID:PF00125, PF16211

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2B 1.1
Chain IDs:D, H
Chain Length:123
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P02281 Pfam ID:PF00125

Polymer Type:polydeoxyribonucleotide
Molecule:Widom 601 sequence
Chain IDs:I
Chain Length:160
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:Widom 601 sequence
Chain IDs:J
Chain Length:160
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Chromodomain-helicase-DNA-bin
Gene (Uniprot):CHD1L
Chain IDs:K
Chain Length:872
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q86WJ1 Pfam ID:PF00176, PF00271

Ligand Molecules

Primary Citation

Activation intermediate of ALC1/CHD1L bound to a PARylated nucleosome

Bridges, H.R, Bacic, L, Deindl, S, Gaullier, G.Show

Biorxiv ? ? ? (2025)

DOI: 10.1101/2025.11.10.687450

Primary Citation of related structures

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