9SZT image
Deposition Date 2025-10-15
Release Date 2025-12-31
Last Version Date 2026-03-04
Entry Detail
PDB ID:
9SZT
Keywords:
HYDROLASE
Title:
Co-chaperone Bag1-bound human 26S proteasome in SBAG1.2 state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SZT validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC2
Chain IDs:PA (auth: A)
Chain Length:376
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC1
Chain IDs:QA (auth: B)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 2 of 26S proteasome r
Gene (Uniprot):PSMC5
Chain IDs:RA (auth: C)
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC4
Chain IDs:SA (auth: D)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC6
Chain IDs:TA (auth: E)
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A0A087X2I1 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC3
Chain IDs:UA (auth: F)
Chain Length:908
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:A (auth: G), N (auth: g)
Chain Length:246
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P60900 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:B (auth: H), O (auth: h)
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25787 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:C (auth: I), P (auth: i)
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:D (auth: J), Q (auth: j)
Chain Length:248
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O14818 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform Long of Proteasome su
Gene (Uniprot):PSMA1
Chain IDs:E (auth: L), S (auth: l)
Chain Length:269
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25786 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:F (auth: M), T (auth: m)
Chain Length:255
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25788 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:G (auth: N), U (auth: n)
Chain Length:239
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28072 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:H (auth: O), V (auth: o)
Chain Length:277
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q99436 Pfam ID:PF00227, PF12465
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:I (auth: P), W (auth: p)
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49720 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:J (auth: Q), X (auth: q)
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49721 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:K (auth: R), Y (auth: r)
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28074 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:L (auth: S), Z (auth: s)
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P20618 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:M (auth: T), AA (auth: t)
Chain Length:264
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28070 Pfam ID:PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD1
Chain IDs:JA (auth: U)
Chain Length:953
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99460 Pfam ID:PF21505, PF01851, PF13646, PF18004 EC:5.6.1.5
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD3
Chain IDs:KA (auth: V)
Chain Length:534
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43242 Pfam ID:PF01399, PF08375, PF25573
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD12
Chain IDs:OA (auth: W)
Chain Length:456
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00232 Pfam ID:PF22241, PF01399, PF18098
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD11
Chain IDs:LA (auth: X)
Chain Length:230
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00231 Pfam ID:PF18055, PF01399, PF18503
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD6
Chain IDs:MA (auth: Y)
Chain Length:389
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15008 Pfam ID:PF10602, PF01399, PF21154
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD7
Chain IDs:NA (auth: Z)
Chain Length:324
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P51665 Pfam ID:PF01398, PF13012
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD13
Chain IDs:EA (auth: a)
Chain Length:376
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UNM6 Pfam ID:PF22037, PF01399
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD4
Chain IDs:FA (auth: b)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P55036 Pfam ID:PF13519, PF02809
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:GA (auth: c)
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00487 Pfam ID:PF01398, PF23594
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD8
Chain IDs:HA (auth: d)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P48556 Pfam ID:PF10075
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome complex subuni
Gene (Uniprot):SEM1
Chain IDs:IA (auth: e)
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60896 Pfam ID:PF05160
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD2
Chain IDs:CA (auth: f)
Chain Length:908
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13200 Pfam ID:PF17781, PF01851, PF18051
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:R (auth: k), BA (auth: K)
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28066 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:BAG family molecular chaperon
Gene (Uniprot):BAG1
Chain IDs:DA (auth: x)
Chain Length:230
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99933 Pfam ID:PF00240, PF02179
Ligand Molecules
ADP
ATP
Primary Citation
Structures of the 26 S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer.
Sci Adv 12 eadz3026 eadz3026 (2026)
PMID: 41719407 DOI: 10.1126/sciadv.adz3026
Primary Citation of related structures
9SZT
Feedback Form
Name
Email
Institute
Feedback