ISDA: 9SZJ

Deposition Date 2025-10-14

Release Date 2026-02-18

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9SZJ

Keywords:

TRANSFERASE

Title:

Crystal structure of Y1230H c-MET bound by capmatinib.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.29 Å

R-Value Free:

0.30

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hepatocyte growth factor rece
Gene (Uniprot):MET
Chain IDs:A
Chain Length:309
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P08581 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1JRF

Primary Citation

Molecular Basis of c‐MET Inhibition by Approved Small Molecule Drugs: A Structural Perspective.

Russell, I.C, Bachurska-Szpala, P, van Beek, L, Michaelides, I.N, Phillips, C, Snijder, A, Stubbs, C.J, Collie, G.W.Show

Acs Med.Chem.Lett. 17 590 597 (2026)

PMID: 41847658 DOI: 10.1021/acsmedchemlett.5c00713

Primary Citation of related structures

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