9SRI image
Deposition Date 2025-09-24
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9SRI
Keywords:
DNA BINDING PROTEIN
Title:
Human DNA polymerase epsilon bound to DNA blunt end
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Trichoplusia ni, Escherichia coli bl21(de3), Synthetic construct
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SRI validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA polymerase epsilon cataly
Gene (Uniprot):POLE
Chain IDs:A
Chain Length:1200
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q07864 Pfam ID:PF03104, PF22634 EC:2.7.7.7
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proliferating cell nuclear an
Gene (Uniprot):PCNA
Chain IDs:B, C, D
Chain Length:261
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P12004 Pfam ID:PF00705, PF02747
Polymer Type:polydeoxyribonucleotide
Molecule:Primer DNA oligonucleotide
Chain IDs:E (auth: P)
Chain Length:24
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polydeoxyribonucleotide
Molecule:Template DNA oligonucleotide
Chain IDs:F (auth: T)
Chain Length:38
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
SF4
Primary Citation
Cryo-EM maps of human DNA polymerase epsilon should be reevaluated in light of its unexpected behavior in vitro.
Proc.Natl.Acad.Sci.USA 123 e2533320123 e2533320123 (2026)
PMID: 41790928 DOI: 10.1073/pnas.2533320123
Primary Citation of related structures
9SRI
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