ISDA: 9SPA

Deposition Date 2025-09-16

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9SPA

Keywords:

HYDROLASE

Title:

Apo ACE2 extracellular domain

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.23

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 41 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Processed angiotensin-convert
Gene (Uniprot):ACE2
Chain IDs:A (auth: C)
Chain Length:609
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYF1 Pfam ID:PF01401 EC:3.4.15.1

Ligand Molecules

MLA

Primary Citation

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Romanyuk, Z, Bettin, G, Brear, P, Linciano, S, Mazzocato, Y, Bonadies, S, Zanotto, I, Mazzucco, C, Monferone, A, Soler, M.A, Pasut, G, Martin, S, Scarso, A, Heinis, C, Rothenberger, S, Hyvonen, M, Angelini, A.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41875055 DOI: 10.1021/acs.jmedchem.5c02876

Primary Citation of related structures

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