9SNP image
Deposition Date 2025-09-11
Release Date 2026-04-01
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9SNP
Keywords:
LIGASE
Title:
VHL/Elongin B/Elongin C complex with compound 60
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.70 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.22
Space Group:
P 41 2 2
9SNP validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Elongin-B
Gene (Uniprot):ELOB
Chain IDs:A, D, G, J
Chain Length:104
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q15370 Pfam ID:PF00240
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Elongin-C
Gene (Uniprot):ELOC
Chain IDs:B, E, H, K
Chain Length:97
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q15369 Pfam ID:PF03931
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:von Hippel-Lindau disease tum
Gene (Uniprot):VHL
Chain IDs:C, F, I, L
Chain Length:162
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P40337 Pfam ID:PF01847, PF17211 EC:2.3.2.B13
Ligand Molecules
A1JO8
Primary Citation
Modulation of VHL binding affinity improves selectivity of PROTACs targeting BRM (SMARCA2) over BRG1 (SMARCA4)
RESULTS CHEM 24 103211 ? (2026)
DOI: 10.1016/j.rechem.2026.103211
Primary Citation of related structures
9SNP
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