ISDA: 9RVT

Deposition Date 2025-07-08

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9RVT

Keywords:

HYDROLASE

Title:

ACE2 extracellular domain in complex with the macrocyclic peptide GR1.4

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.39 Å

R-Value Free:

0.29

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Processed angiotensin-convert
Gene (Uniprot):ACE2
Chain IDs:A, B, D, G
Chain Length:609
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9BYF1 Pfam ID:PF01401 EC:3.4.15.1

Polymer Type:polypeptide(L)
Molecule:macrocyclic peptide GR1.4
Chain IDs:C, E, F, H
Chain Length:14
Number of Molecules:4
Biological Source:synthetic construct

Primary Citation

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Romanyuk, Z, Bettin, G, Brear, P, Linciano, S, Mazzocato, Y, Bonadies, S, Zanotto, I, Mazzucco, C, Monferone, A, Soler, M.A, Pasut, G, Martin, S, Scarso, A, Heinis, C, Rothenberger, S, Hyvonen, M, Angelini, A.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41875055 DOI: 10.1021/acs.jmedchem.5c02876

Primary Citation of related structures

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