9RRY image
Deposition Date 2025-06-30
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9RRY
Keywords:
Title:
Crystal structure of the human METTL3-METTL14 in complex with compound 1 (AD-79)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.91 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.22
Space Group:
P 32 2 1
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N6-adenosine-methyltransferas
Gene (Uniprot):METTL3
Chain IDs:A
Chain Length:228
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N(6)-adenosine-methyltransfer
Gene (Uniprot):METTL14
Chain IDs:B
Chain Length:307
Number of Molecules:1
Biological Source:Homo sapiens
Primary Citation
Ligand-Induced Opening of a Cryptic Pocket in METTL14
Acs Bio Med Chem Au ? ? ? (2026)
DOI: 10.1021/acsbiomedchemau.5c00184
Primary Citation of related structures
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