ISDA: 9RME

Deposition Date 2025-06-18

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9RME

Keywords:

VIRAL PROTEIN

Title:

Hybrid NMR/Xray structure of SARS-CoV2 macrodomain (nsp3b) in complex with the sulfamoyl derivative of GS-441524

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus (Taxon ID: 2901879)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

100

Conformers Submitted:

Selection Criteria:

structures with the least restraint violations

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Papain-like protease nsp3
Chain IDs:A
Chain Length:173
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus

UniProt ID:P0DTC1 Pfam ID:PF01661

Ligand Molecules

A1JHT

Primary Citation

Structure-Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus-2 Nsp3 Macrodomain.

Krishnathas, R, Mineev, K.S, Fourkiotis, N.K, Touret, F, Sideras-Bisdekis, C, Tsika, A.C, Gande, S.L, Linhard, V, Sreeramulu, S, Lennartz, F, Weiss, M.S, Coutard, B, Spyroulias, G.A, Schwalbe, H.Show

Chembiochem 26 e202500593 e202500593 (2025)

PMID: 41176653 DOI: 10.1002/cbic.202500593

Primary Citation of related structures

Feedback Form