ISDA: 9RDF

Deposition Date 2025-06-02

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9RDF

Keywords:

HYDROLASE

Title:

Liver Pyruvate kinase in complex with a phthalazine-based fluorescent probe IV

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.62 Å

R-Value Free:

0.27

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform L-type of Pyruvate ki
Gene (Uniprot):PKLR
Chain IDs:A, B, C, D
Chain Length:545
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P30613 Pfam ID:PF00224, PF02887 EC:2.7.1.40

Ligand Molecules

A1JEB

FBP

OXL

PEG

Primary Citation

Potent Fluorescent Probe for Target-Engagement Studies of Allosteric Pyruvate Kinase Modulators.

Nilsson, O, Valaka, A.P, Haversen, L, Bogucka, A, Koteles, I, Brear, P, Rutberg, M, Gunnarsson, A, Hyvonen, M, Grotli, M.Show

Angew.Chem.Int.Ed.Engl. 64 e202513969 e202513969 (2025)

PMID: 40884041 DOI: 10.1002/anie.202513969

Primary Citation of related structures

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