ISDA: 9R18

Deposition Date 2025-04-25

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9R18

Keywords:

PROTEIN BINDING

Title:

Structure of Sortilin ECD in complex with TNFa-targeting SORTAC

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Cricetulus griseus

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.25

R-Value Work:

0.21

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sortilin
Gene (Uniprot):SORT1
Mutagens:V650M
Chain IDs:A
Chain Length:762
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q99523 Pfam ID:PF15902, PF15901

Ligand Molecules

A1JCL

NAG

Primary Citation

Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins.

Gustafsen, C, Vilstrup, J, Kristensen, M, Koster, D, Lende, J, Larsen, C, Simonsen, A, Graversen, A, Olsen, D, Pallesen, L.T, Vaegter, C.B, Kresse, J.C, Schou, M, Weyer, K, Etzerodt, A, Palmfeldt, J, Kaas, M, Qureshi, O, Harrison, N, Cowley, J, Barnes, N, Galland, F, Naquet, P, Mazarakis, S.M.M, Greve, D, Quattropani, A, Glossop, P, Whitlock, G, Jensen, K.T, Nielsen, S.F, Madsen, P, Glerup, S.Show

Cell Chem Biol ? ? ? (2026)

PMID: 41903545 DOI: 10.1016/j.chembiol.2026.03.002

Primary Citation of related structures

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