ISDA: 9QKQ

Deposition Date 2025-03-20

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9QKQ

Keywords:

TRANSCRIPTION

Title:

Crystal structure of hTEAD4 YAP binding domain (hTEAD4-YBD) in complex with peptide 6

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.74 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transcriptional enhancer fact
Gene (Uniprot):TEAD4
Chain IDs:A, B
Chain Length:222
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q15561 Pfam ID:PF17725

Polymer Type:polypeptide(L)
Molecule:peptide 6
Chain IDs:C, D
Chain Length:17
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

EDO

MYR

PO4

Primary Citation

Deciphering the structural and functional properties of interface 3 and lipidation pocket of hTEAD4 to develop new Hippo Pathway inhibitors through fluorescence anisotropy

Malpezzi, G, Scalvini, L, Tagliazucchi, L, Chiaravalle, A, Aiello, D, Saporito, G, Illuminati, D, Pacifico, S, Lopresti, L, Raucci, L, Guerrini, R, Pozzi, C, Venturelli, A, Ponterini, G, Mor, M, Costi, M.P.Show

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Primary Citation of related structures

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