9QDK image
Deposition Date 2025-03-06
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9QDK
Keywords:
OXIDOREDUCTASE
Title:
Trypanosoma brucei PTR1 in complex with fragment L330 and compound F46
Biological Source:
Source Organism(s):
Trypanosoma brucei brucei (Taxon ID: 5702)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.90 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 1 21 1
9QDK validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pteridine reductase
Gene (Uniprot):PTR1
Chain IDs:A, B, C, D
Chain Length:288
Number of Molecules:4
Biological Source:Trypanosoma brucei brucei
UniProt ID:O76290
Ligand Molecules
ACT
AX8
GOL
NDP
QY8
Primary Citation
Identification and optimization of Trypanosoma Brucei Pteridine-Reductase 1 Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
To Be Published ? ? ? (?)
Primary Citation of related structures
9QDK
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