ISDA: 9Q7Y

Deposition Date 2025-08-25

Release Date 2026-04-01

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9Q7Y

Keywords:

MEMBRANE PROTEIN

Title:

Zymogen ADAM17- iRhom1 Cytoplasmic Deletion (365) Complex Bound by the MEDI3622 Fab

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.35 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Inactive rhomboid protein 1
Chain IDs:A
Chain Length:462
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Disintegrin and metalloprotei
Chain IDs:D (auth: B)
Chain Length:671
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MEDI3622 Fab Light Chain
Chain IDs:B (auth: C)
Chain Length:106
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MEDI3622 Fab Heavy Chain
Chain IDs:C (auth: D)
Chain Length:118
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules