ISDA: 9PZF

Deposition Date 2025-08-11

Release Date 2026-03-11

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9PZF

Keywords:

ONCOPROTEIN

Title:

Structure of KRAS G12C bound to Compound 4

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.84 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12C variant, C51S, C80L, C118S
Chain IDs:A, B
Chain Length:187
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

A1CQ2

GDP

Primary Citation

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Endres, N.F, Do, S, Mroue, R, Terrett, J.A, Saabye, M, Oh, A, Hunsaker, T, Chan, E, Tran, J.C, Nguyen, L.K, Lian, Q, Ma, T.P, Garner, T, Gerosa, L, Beresini, M, Boudreau, A, Bronner, S.M, Cyr, P, Ishisoko, N, Izrayelit, Y, Jiang, F, Kellar, T, La, H, Labadie, S, Lardy, M, Liu, L, Liu, W, Miller, S, Rudolph, J, Plise, E, Sellers, B.D, Shao, C, Wang, W, Wang, Y, Wei, W, Wong, S, Yu, C, Yu, K, Yuen, P.W, Zang, R, Zhang, C, Zhou, Y, Zhu, X, Quinn, J.G, Ye, X, Kiefer, J.R, Mao, J, Evangelista, M, Merchant, M, Landry, M.L, Malhotra, S, Purkey, H.E.Show

J.Med.Chem. 69 5147 5165 (2026)

PMID: 41766690 DOI: 10.1021/acs.jmedchem.5c02272

Primary Citation of related structures

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