ISDA: 9PQD

Deposition Date 2025-07-22

Release Date 2025-08-20

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9PQD

Keywords:

MEMBRANE PROTEIN

Title:

Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.29 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-2A adrenergic receptor
Gene (Uniprot):ADRA2A
Chain IDs:A (auth: R)
Chain Length:491
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P08913 Pfam ID:PF00001

Ligand Molecules

A1CIZ

Primary Citation

Large Library Docking for Polypharmacology.

Wu, Y, Vigneron, S, Braz, J, Srinivasan, K, Fink, E.A, Huang, X.P, Xu, X, Huebner, H, Kim, J.Y, Wang, J, Pfeiffer, T, Sakamoto, K, Radchenko, D.S, Rodriguiz, R.M, Moroz, Y.S, Irwin, J.J, Gmeiner, P, Billesboelle, C, Roth, B.L, Basbaum, A.I, Manglik, A, Wetsel, W.C, Shoichet, B.K.Show

J.Med.Chem. 69 6210 6229 (2026)

PMID: 41712624 DOI: 10.1021/acs.jmedchem.5c03810

Primary Citation of related structures

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